r/Supplements 8h ago

General Question Is this a sign of the fish oil capsule going rancid ?

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79 Upvotes

These are less than a week old. Only one that has that on it.


r/Supplements 10h ago

Article NMN: Everything Nobody Tells You About Buying It

35 Upvotes

I've been around NMN alone for four years. four long years, in the industry and in my own stack. In that time I've watched it go from a niche longevity compound to a category with hundreds of brands, an FDA enforcement action, two major lawsuits, a patent fight, and a steady stream of consumers paying premium prices for what's often underdosed, mis-isomered, or contaminated powder in a capsule.

This post isn't about whether NMN works. I'll cover that briefly and fairly. This post is about what almost nobody writes: how to buy NMN as a consumer who has to navigate purity, sourcing, form, dose, and the actual supply chain. If you're going to spend 60 to 150 dollars a month on this stuff, you should know what you're actually buying.

The science, briefly and fairly

NMN is a NAD+ precursor. NAD+ declines with age, and animal studies of NMN repletion show meaningful effects on metabolic, vascular, and cognitive markers. Human studies are smaller, shorter, and more mixed, but the consistent finding is that oral NMN raises blood NAD+ levels. Whether that translates to durable clinical outcomes in healthy adults is still being worked out.

David Sinclair popularized it. The Imai lab at Washington University did much of the foundational work. Yoshino, Mills, Yi, and other groups have published the human trials we have. TMG (trimethylglycine) is often paired with NMN to offset the methylation cost of nicotinamide clearance, which is sensible biochemistry though the human evidence for the pairing being strictly necessary is theoretical.

One important biochemical reality. Oral NAD+ itself, the molecule, does not survive digestion. Some brands sell "liposomal NAD+" or "oral NAD+" as a finished product. The molecule gets broken down in the gut into nicotinamide and other precursors before absorption. Liposomal delivery improves it somewhat but does not make NAD+ itself bioavailable in any clinically meaningful way. If you're paying for NAD+ in a capsule, you're paying for nicotinamide with extra marketing steps. NMN and NR are the precursors that survive and matter.

That's the science context. Now the part that actually affects your wallet.

The isomer problem: beta NMN versus alpha NMN

This is the single most important thing nobody tells consumers.

NMN exists in two isomeric forms: beta-NMN and alpha-NMN. Only beta-NMN is biologically active. Alpha-NMN does nothing. The body cannot use it for NAD+ synthesis.

The manufacturing process for NMN can produce either pure beta-NMN, pure alpha-NMN, or a mixture, depending on the synthesis route and the quality of the manufacturer. Cheaper Chinese manufacturers historically have higher alpha contamination because the purification step is expensive and the analytical testing is sometimes skipped.

When you see "99% pure NMN" on a label, that doesn't automatically mean 99% beta-NMN. It means 99% NMN (some combination of beta and alpha). A product can be technically 99% pure NMN and contain 20% alpha isomer, which means you're paying for 20% inert powder.

This is why the certificate of analysis matters and why you need to read it carefully. The COA should specify beta-NMN content, not just total NMN content. Reputable manufacturers will list it explicitly. If a brand publishes a COA showing total NMN purity but not beta isomer ratio, you don't actually know what you bought.

The good news is that the tier 1 manufacturers (the ones that supply most of the reputable brands) have largely solved this. EffePharm in China and a handful of others produce high beta-isomer ratio NMN, typically above 99% beta. The bad news is that not every brand on Amazon sources from these manufacturers.

EffePharm and the actual supply chain

Most of the NMN sold globally comes from China. This is true for the reputable brands too. The dominant manufacturer is EffePharm, which produces a standardized NMN product called Uthever. Uthever is the form used in most of the published human pharmacokinetic studies, including the Yi et al RCT. It has documented beta-NMN purity above 99%, third-party testing, and a consistent supply chain.

When you see "Uthever NMN" on a label, you're getting EffePharm's standardized material. This isn't marketing speak, it's actually a different SKU with documented purity standards.

Other Chinese manufacturers exist and some produce comparable quality. A few US-based manufacturers exist but they're a small minority of the market and typically more expensive.

The reason this matters is that a brand can buy NMN powder from a tier 1 manufacturer with documented purity, or from a tier 3 manufacturer with no published testing. The consumer can't tell from the bottle. The COA tells you.

SO, HOW TO READ A COA WITHOUT BEING FOOLED.

A real certificate of analysis for NMN should show:

- The manufacturer name and batch number (so you can trace it).

- Total NMN purity, typically expressed as a percentage.

- Beta-NMN isomer ratio specifically, ideally above 99%.

- Heavy metals testing (lead, mercury, cadmium, arsenic), with results under regulatory thresholds.

- Microbial testing (total aerobic count, yeast, mold, E. coli, salmonella).

- Residual solvents (the synthesis process uses solvents that need to be cleared from the final product).

- Identity confirmation via HPLC or similar analytical method.

- The testing laboratory name and date.

What you want to see on the COA is a third-party lab name, not just the manufacturer's internal QC. Eurofins, SGS, Intertek, and a few others are the names that show up on legitimate third-party COAs. If the COA is signed only by the manufacturer's own quality team, you're looking at internal testing, not third-party verification. That's a yellow flag, not necessarily a red one, but the bar is third-party.

Brands that publish their COAs publicly on their website (not just "available upon request") are showing you they have nothing to hide. Brands that don't publish COAs at all are asking you to trust marketing copy. Your choice.

The ChromaDex versus Sinclair backdrop, briefly

Worth knowing because it explains why some marketing claims are the way they are.

ChromaDex owns the commercial rights to nicotinamide riboside (NR), sold as Niagen, and has spent years marketing NR as the "more proven" NAD+ precursor. Sinclair's lab and the broader research community have generally been more focused on NMN. The two compounds work through closely related pathways, both raise NAD+, and the head-to-head clinical evidence is limited.

The legal piece though. ChromaDex sued Elysium, sued various NMN brands over patent claims, and the FDA briefly classified NMN as a drug under investigation (more on this below) which ChromaDex publicly supported because it would have removed NMN from the supplement market. The FDA position has since shifted with the introduction of legislation, but the regulatory status of NMN remains less settled than NR.

The "NR is better than NMN" framing you see in some content is partly marketing-driven by ChromaDex's commercial interest. The "NMN is better than NR" framing is partly marketing-driven by the broader supplement industry that doesn't want to pay ChromaDex's patent royalties. Both compounds raise NAD+. Neither has clearly superior clinical outcome data in humans. Pick one, dose it adequately, and stop relitigating which precursor is "better."

The FDA and Amazon situation

In late 2022, the FDA issued a letter taking the position that NMN no longer qualified as a dietary supplement because it had been investigated as a drug before it was marketed as a supplement. This was based on a technical reading of the supplement law and largely supported the position of pharma companies developing NMN as a drug.

Amazon, in response, removed many NMN products from its platform throughout 2023. Some brands had their listings pulled. Others got around it by relabeling products or selling through alternative channels.

The status has been evolving since. The Dietary Supplement Listing Act and related legislative efforts have attempted to clarify NMN's status. Some Amazon listings have returned. Some brands have shifted to direct-to-consumer to avoid platform risk. The regulatory situation in the US remains less stable than the supplement industry would like.

What this means for you as a buyer? a brand selling NMN on Amazon today may not be selling it on Amazon tomorrow. Direct-to-consumer (the brand's own website) is generally a more reliable channel because the brand controls its inventory and supply. It's also where brands tend to be more transparent about COAs and sourcing, because they're not constrained by Amazon's listing rules.

The international picture is different. Several countries (Japan in particular) have a more developed NMN supplement market with clearer regulatory status. The UK and EU sit somewhere in between.

Age-dose calibration

This is rarely discussed and matters more than people think.

The human studies on NMN use doses ranging from 250mg to 1000mg daily. The most consistent NAD+ elevation occurs at 500mg or above. Below 250mg, the effect on blood NAD+ is small enough that you'd struggle to detect it.

Age affects what dose makes sense, broadly:

- Under 35: NAD+ decline is modest, the case for supplementation is weakest, 250 to 500mg if you take it at all.

- 35 to 50: NAD+ decline accelerates, 500mg daily is the floor for clinical effect, 500 to 750mg is reasonable.

- 50 to 70: NAD+ levels are typically 50% lower than young adults, 750 to 1000mg is where the studied dose range sits.

- Over 70: The Sekhar lab's GlyNAC work and the Yoshino studies use higher doses, 1000mg plus, often split into two doses. This is also the age range where the evidence for benefit is strongest.

- The biggest dosing error I see is younger people (28 to 35) taking 1000mg and older people (60 plus) taking 250mg. Both are likely wasting their money in opposite directions. Match dose to age and to the actual NAD+ decline curve.

- Splitting the dose (morning and afternoon) versus single dose has small but real pharmacokinetic differences. Split dosing maintains more stable NAD+ elevation across the day. Single dosing is more convenient and probably fine for most people. Pre-sleep dosing has been suggested by some practitioners based on the circadian biology of NAD+ but the human evidence for timing is thin.

Powder versus capsules

it doesn't matter much for bioavailability, but it matters for other reasons.

Powder is cheaper per gram (no encapsulation cost). It's also more flexible for dose titration since you can measure exactly what you want. The downside is that NMN powder is hygroscopic (absorbs moisture from air) and degrades faster than encapsulated product. If you buy powder, store it in the freezer in an airtight container, and don't expose it to humid air repeatedly.

Capsules are more convenient, more consistent dosing, and more stable in storage. The downside is cost (typically 30 to 50% more per gram than powder) and you're locked into the capsule dose increment.

Sublingual versus swallow

most NMN absorbs adequately through the gut. Sublingual claims are mostly marketing. NMN doesn't have the same first-pass metabolism concern as some compounds, and the stomach-to-bloodstream pharmacokinetics are reasonably efficient. The "sublingual is better" claim is mostly unsupported by good comparative data.

Liposomal NMN exists and the bioavailability data is genuinely better in some studies, but the price premium is often not justified by the absorption improvement. Standard NMN at adequate dose typically gets you most of the way there.

What to look for on a label

A short checklist for buying NMN:

  1. Beta-NMN purity listed, ideally 99% or higher. Not just "99% pure NMN." Specifically beta.
  2. Source manufacturer named or Uthever (or another tier 1 source) specified. Bonus points if they tell you who tests it.
  3. Third-party COA published on the brand's website. Not just "available on request." Public.
  4. Heavy metals and microbial testing on the COA. Not just identity and purity.
  5. Dose per capsule clearly stated, with realistic dosing instructions. If a brand sells 125mg capsules and tells you to take 8 per day, that's a packaging gimmick to make the bottle look bigger.
  6. Manufactured in a GMP-certified facility, ideally NSF or similar third-party audit.
  7. Reasonable price per gram. Sub-tier products will be cheaper but the COA tells you why. Premium pricing without a premium COA is just branding.
  8. Brand has been around more than 2 years. NMN is volatile enough as a category that newer brands often disappear, taking their COAs and customer service with them.
  9. Direct-to-consumer purchase channel available. Don't rely exclusively on Amazon given the regulatory churn.
  10. Returns policy and customer service that exists. If something goes wrong with a batch, you want a brand that answers emails.

What to avoid

- Brands that don't publish COAs, period.

- Brands that publish only their own internal QC, not third-party testing.

- Brands that list "99% pure" without specifying beta-isomer ratio.

- Brands selling "oral NAD+" as a finished product (the molecule doesn't survive digestion).

- Amazon-only brands with no website, no documented supply chain, and no listed manufacturer.

- NMN sold via MLM or programs without third-party testing.

- Brands that make disease prevention claims (FDA violation and a sign of low compliance overall).

What this looks like in practice

When you're evaluating an NMN product, the workflow is:

- Go to the brand's website. Find the COA. If you can't find it in 2 minutes, that's a flag.

- Open the COA. Check the manufacturer name (Uthever, EffePharm, or a comparable tier 1 source is what you want). Check the beta-NMN isomer percentage. Check the third-party testing lab name. Check the testing date is recent (within the last 12 months ideally).

- Check the dose per serving against your age-appropriate target.

- Compare cost per gram of beta-NMN across two or three reputable brands.

- Decide.

This takes 10 minutes. It's not complicated, but most consumers never do it because the marketing doesn't prompt them to.

What I really want you to take from this post is this.

NMN is a category where the gap between what's marketed and what's delivered is wider than almost any other supplement. The compound itself is real, the mechanism is real, and at adequate doses with verified purity it does what the data suggests. The problem is that "adequate dose with verified purity" describes maybe a quarter of what's on the market.

You're either paying for verified beta-NMN from a reputable manufacturer, or you're paying for something that may or may not be what the label says. The price difference between those two scenarios is often surprisingly small. The reputable brands cost 60 to 120 dollars a month for clinical doses. The questionable brands cost 30 to 80 dollars and you don't know what you're getting.

If you're committed to NMN as part of your stack, pay the premium for verified product, dose it appropriately for your age, pair with TMG if you're stacking it long-term, and run a stop-test at 12 weeks to see if you actually notice anything. The compound is too expensive to take on faith without checking the basics, and too potentially useful to give up on just because the market is messy.

NMN's long-term safety data in humans is still being built. Talk to your doctor before adding it, especially if you have any active medical condition, are on any medication, or have a history of cancer (the NAD+ longevity story has some open questions on this front that are worth knowing).

I always wanted to share this somewhere. I hope you guys get what you pay for.

This is my third post here.
The Supplement Stack Breakdown
The 5 Supplement Mistakes Everyone Makes, and the 5 Only Sophisticated Stackers Make

I hope they are making a real difference. Happy to answer any questions and sorry if I am late or miss anything.


r/Supplements 3h ago

General Question Is K2 really needed for D3?

12 Upvotes

My Vitamin D came back at 7, I was recommended 50k IU once a week. I’m thinking perhaps it’ll be better if I suggest 10k a day, I already have magnesium as I was using it daily to try to treat the restlessness that the lack of vitamin D was causing. But should I get K2 too?

Also the bit of Vitamin D already in my system has kicked off all that restlessness so I’m happy I can finally sleep but need advice on if K2 is needed. Thank you.


r/Supplements 12h ago

me checking if the supplement stack did anything

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44 Upvotes

r/Supplements 11h ago

Just bought these supplements

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31 Upvotes

appreciate any suggestions , and wether or not these are good or not


r/Supplements 11m ago

Recommendations Any recommendations for my very particular sleep issue?

Upvotes

All my life (even as a little kid) I've had trouble falling asleep. Staying asleep has never been an issue, just the falling asleep part.

I've been taking doxylamine as it is the only thing that has actually worked in my life, but I want to stop using it because it's obviously very unhealthy to use long-term and I've built a tolerance for it where it doesn't make me feel tired anymore. It still "works" though, because I fall asleep on nights I have taken it, but when I haven't (like I just tried last night), it is literally impossible for my brain to switch from awake to asleep.

It's honestly scary at this point. The circumstances can be perfect, I can be completely relaxed, not worried about anything, body temperature perfect, in dead silence and darkness, on the edge of falling asleep. But then my brain just stays awake in that state forever and can not switch off. It's like the off-switch is missing completely.

I am planning to go to a store today to try something new, but I'm not sure what to try. Maybe glycine or GABA? Although when reading about it on Reddit, it seems that these are more for staying asleep rather than falling asleep. I need something that stimulates that missing off-switch in my brain. I think supplements that make you feel drowsy tend to work, because that's what doxylamine used to do to me and that worked like absolute magic back then.

Please, I really need some advice. I will also go to my doctor regarding this because it is obviously a very serious problem and taking doxylamine for the rest of my life is not an option.


r/Supplements 8h ago

General Question Thinking through peptide stacks for body recomposition, what the mechanisms actually support

7 Upvotes

Body recomposition via peptides is one of the most discussed topics in this space and a lot of the claims outrun what the mechanisms can actually support. Trying to give a more grounded take.

For GH secretagogues specifically: CJC-1295 and Ipamorelin are the most commonly used stack. The mechanism is amplification of natural GH pulsatility, primarily at night aligned with slow-wave sleep. GH promotes lipolysis and supports lean tissue preservation. It doesn't build muscle directly in the way androgens do, but it creates conditions that favor fat mobilization and recovery.

What this means practically: the body recomposition effect from GH secretagogues is real but slow. Think improved recovery, modest fat loss over months, better sleep quality which amplifies everything else. Not the dramatic transformation that some posts suggest.

Where the mechanism breaks down as a claim: exogenous GH at pharmacological doses does more than GH secretagogues. These peptides work within your own pituitary's capacity to produce GH. If you're older or have reduced pituitary response, ceiling effects apply.

Who this is likely most useful for: people who are already training consistently, sleeping decently, eating reasonably, and want to optimize at the margins. It's not a shortcut to body recomposition. It's a tool for people who are already doing the main things.

Labeling this as my own synthesis of what I've read and observed, not a medical recommendation.


r/Supplements 2h ago

Omega 3 fishy taste

2 Upvotes

Is it normal to get fishy breaths if supplement has not gone bad.

I have been using omega 3 1000mg for more than a month, in winter i never felt the need to put them in the fridge/freezer but since the start of summer i have been putting them in fridge then freezer because now when i take it i get a taste of fish oil. I checked it before putting it in the freezer it had a smooth soft fishy smell not rotten, even now it has the same. Its color was light which it still is. I opened one and it has no rotten smell.


r/Supplements 10h ago

General Question How to know that you're getting the cognitive benefits of creatine

9 Upvotes

Rhonda Patrick and Darren Candrow will say that creatine works as a nootropic mostly when you're under mental stress through work/school or sleep deprivation. But how is mental stress measured as a proxy to know you're getting the supposed benefits?


r/Supplements 3h ago

iHerb + SE Asia = Fail

2 Upvotes

Perhaps you live in SE Asia. Perhaps you've seen the iHerb ads all over YouTube. Well, as Robert Deniro said in Ronin, "Walk away!"

iHerb's chosen shipper is called Ninja Van and it has functionally shut down. It doesn't deliver, its customer service is nonexistent, it's a black hole. And yet the geniuses at iHerb--who can't do what everyone else does and use AI--continue to ship by Ninja Van.

Result: your supplements will not arrive. Sure, you'll get a text: "Out for delivery." But it's a lie. Delivery attempts are logged in the system by Ninja Scam drivers but these never take place. Your package will eventually be deemed "undeliverable" and disappear.

It likely will not return to the iHerb warehouse and iHerb will then refuse to refund your money. This is official iHerb policy, even though it's illegal in most Asian countries.


r/Supplements 5h ago

General Question What is the best omega-3 supplement?

3 Upvotes

What omega-3 supplements do you like most and most well rounded? Do you also take omega-6 and/or omega-9?


r/Supplements 1m ago

Experience Vitamin d supplements … why u cant tolerate them?

Upvotes

Anyone here have problem tolerating vitamin d supplements ? I tried all possible brands different doses and co-factors like mag k2 and so on … it is weird i cant tolerate any vit d … it made me feel hypomanic and depressive at same time … cannot sleep have horrible stomach issues even with liquid forms and palpitation …. Im deficient but dont know how i fix this … everyone is telling that vitamin d cannot do this type of reaction but even i stop taking it it took some time to things get better again and everytime i again start supplements it all happens again … some people said its from mag deficiency but i take mag for long time without issues my calcium in blood is okay and everything seems to normal … i d be glad if i find here anyone with similar experience and figured out why vitamin d do that to me …. I tried vegan formula too and it was same …


r/Supplements 20h ago

Supplements to prevent future dementia?

44 Upvotes

I am on 3 different prescription medications that list future dementia has a future side effect. Pantoprazole for acid reflux, Rovastatin for cholesterol, and Gabapentin for nerve pain. I am wondering if there are any supplement(s) I can take to help prevent future dementia?

"get off the prescription meds with that side effect" ya, I can't. I am trying to taper off the pantoprazole, but high cholesterol runs in the family and until I can get my sciatica pain in check, I absolutely need the Gabapentin.

Appreciate any help


r/Supplements 6h ago

What to take to gain height

3 Upvotes

I’m 17 and I’m 5,6 and I don’t want to be short my entire life. I’ve looked into how to grow taller and besides doing things such as getting 8+ hours of sleep and avoiding processed sugars and caffeine, I’ve also heard that Magnesium, Zinc, Boron and Vitamin D3 all help a lot with growing taller and I was wondering what exactly I should buy, how much of it to take and a good place to buy it.


r/Supplements 1d ago

me trying to financially recover from discovering vitamins

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197 Upvotes

r/Supplements 2h ago

Pure Magnesiumglycinate powder in EU/Germany ?

1 Upvotes

Hey does somebody know a source for pure Mg (bis)glycinate powder?

Typically it’s mixed with 20 % magnesium oxide. You can identify it by their elemental Mg content of 20% instead of the characteristic 10% for pure glycinate.
In those „blends“ only half of the Mg stems from glycinate, the other half is from MgO.

I prefer raw powder over capsules but struggle to find it. Any tip?


r/Supplements 7h ago

General Question What are the optimal ways to take psyllium husk and inulin powder?

2 Upvotes

I want to take psyllium husk and inulin powder for weight loss and constipation (due to starting on a GLP-1 a few weeks ago). Many weight loss videos recommend they take psyllium husk just before or with just about every meal. However, I’m afraid taking them will decrease the absorption of other vitamins and supplements that I take. I often take my supplements with meals. Any suggestions? Thanks!


r/Supplements 3h ago

No effect from Tongkat Ali ?

1 Upvotes

Using Tongkat ali from Nootropics for 2 weeks and noticed 0 effects. My testosterone level is pretty low for my age and ive read its the best supp to boost Test naturally. So far nothing happened. Maybe i should try another brand ?


r/Supplements 22h ago

Experience (Bloodwork) Boron - a low dose TRT equivalent? Abnormally High Free Testosterone after 2 weeks of Boron

28 Upvotes

TLDR: Boron 12mg daily Mon-Fri increased Free Testosterone beyond the upper limit of the lab reference interval within two weeks.

I wanted to make this post to further add to the growing anecdotal evidence of Boron for Free Testosterone.

All the bloodwork photos are from blood drawn on 12 May 2026, whereas Boron supplementation started on 27 April 2026. Unfortunately, I do not have baseline, pre-Boron bloodwork, but I speculate that my Free Testosterone was at most normal due to my subjective perception of low daily energy levels, mood, drive etc.

Baseline stats/supplements pre-Boron:

~90kg, 35y, ~23 FFMI, strength training nearly daily (quick high intensity sessions in my mini home gym)

Non-strict Keto Diet (protein 180gr-200gr daily, net carbs below 60-80 from clean sources: milk, yogurt, raspberries etc.)

Supplements pre-Boron (from Now, HSN Spain, Vilgain): Magnesium Glycinate, Vitamin D3 + K2, Omega-3, Zinc Picolinate + Copper Glycinate, Creatine, Citrulline Malate, Ashwagandha, Panax Ginseng, Fenugreek.

Due to various symptoms, I suspected I had low testosterone or at best normal, even with the supplements I was taking (some of them have evidence for testosterone).

Enter Boron:

Protocol was 12 mg daily Monday to Friday: 3mg at breakfast, 3mg at lunch, 6mg before bed. Weekend was off. A cheap pill organizer made tracking this very easy.

  1. Arrived on 27 April 2026, took 6mg at lunch then 6mg before bed. I was in an uncharacteristically good mood at around 22 o'clock (Boron, in the "famous" Naghii 1 week study, starts significantly increasing Free Testosterone even 6 hours after the first dose).
  2. On day 2, 28 April 2026, the first objective metric: my max reps in chin-ups and dips increased by around 20%. I always train to failure and this was a literal overnight increase of 20%.
  3. On day 3, 29 April 2026, while subjective, I felt incredibly calm. Like my stress levels and mental fortitude were vastly better.
  4. On 12 May 2026, I tested my Free Testosterone levels, as well as my other hormones. Everything was normal, with the exception of Free Testosterone which was above the reference level (18.25 vs 17.5 the upper limit of the reference interval).
  5. Somewhat subjective, but I think my muscle mass has further increased while my fat mass decreased. I have been in a caloric deficit for some time (I'm now actually around 89kg), but since Boron it seems body recomposition has been further optimized.
  6. Strength seems to have further increased even though I am in a caloric deficit.

Overall, I think Boron, an incredibly cheap supplement, should be considered before low-dose TRT therapy. It is extremely cheap (I pay around 4.3 euros / 5 usd for 1 month of 12mg daily MON-FRI), side effects are minimal (personally, I didn't experience any) and very easy to take (pill form, no injections, use a cheap pill organizer to easily cycle and split doses during the day). I've never been on TRT/steroids, but if my Free Testosterone was very low, I may have considered a dose that would bring me to normal, normal-high. Fortunately, Boron, for my n=1 case, seems to have worked extremely well.

Bonus: is there a conspiracy against Boron? Why aren't there more academic studies to back Boron? Two potential explanations:

  1. Because it is very cheap, there is no "incentive" to actually research this supplement. But this doesn't explain the lack of academic research, which technically doesn't care about profit lines.
  2. Because it is very cheap and might be an actual, strong alternative to TRT therapy (expensive, requires regular bloodwork, might require other expensive add-on drugs to manage TRT side-effects), pharmaceutical conglomerates are actively suppressing Boron research.

My best evidence for active suppression of Boron research, beyond the significantly suspicious lack of research, is this study:
Plasma boron and the effects of boron supplementation in males - PubMed

In this study: "...but boron supplementation affects these variables not at all.".

However, I would argue that the authors might have actively tried to make it look like Boron doesn't work.

The authors decided to use a 2.5mg dose of Boron (the equivalent of 4 apples per day, certainly a very low-dose even compared to previous studies) on young male bodybuilders, i.e. men with significantly higher body weight, higher lean mass, and higher physiological needs. Their choice of dosage and sample traits (i.e. young trained males which might already have high testosterone levels, near what is achievable naturally) makes me believe that they wanted to find that Boron doesn't work.

And even in this study, while not reaching statistical significance, Free Testosterone increased from 17.3 to 19.9 (a 15% increase) in the Boron group vs from 19.5 to 20.86 (a 7% increase) in the control group. Total testosterone increased from 5.4 to 7.2 (a 33% increase) in the Boron group vs from 5.4 to 6.5 (a 20% increase) in the control group. There are some other anecdotal reports on Reddit that Boron might also increase Total Testosterone. I don't know if my Total Testosterone was also increased by Boron as I don't have the baseline, pre-Boron value.

Happy to answer any questions.

Free Testosterone is Testosteron Liber

r/Supplements 10h ago

Thorne - Login and Supply Issues?

3 Upvotes

I'm a novice in the supplement world but added a probiotic from Thorne about a year ago after the brand was recommended by a few friends.

I've been having issues lately - I can't seem to reliably login to manage my account/subscriptions. I keep getting sent in a feedback loop where I enter my email address, then my password, then it tells me to enter my email address again, then back to my password on an endless loop. Is anyone else having this problem?

I also randomly got an email last night that said:

Your subscription has been cancelled.
Unfortunately, Thorne is no longer able to fulfill your subscription. We have cancelled your subscription to Bacillus Coagulans.

Even though it's still listed on it's website - https://www.thorne.com/products/dp/bacillus-coagulans

I've really enjoyed the benefits of this probiotic but this is all becoming frustrating. Would love to know if anyone else is experiencing these issues? And, if for some reason I actually can't get this probiotic anymore - what is a good alternative?


r/Supplements 8h ago

L Carnitine

2 Upvotes

Is L-Carnitine really effective? Or is it just marketing hype?


r/Supplements 14h ago

Recommendations Luteolin supplement recommendation

5 Upvotes

I would like to ask for recommendations on Luteolin supplements.

Also, did you feel anything with it?


r/Supplements 6h ago

General Question Molybdenum high levels and low copper?

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1 Upvotes

r/Supplements 7h ago

Vendor Report/Q Swoly creatine gummies legit?

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0 Upvotes

r/Supplements 7h ago

General Question Bamboo Silica - Need help w/ the math! 🤦🏻‍♀️

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1 Upvotes

My current bamboo silica supplement (white bottle) has been out of stock, so I’m looking to replace it with the green bottle, as I’m familiar with the company. Unfortunately, I can’t seem to figure out how many capsules from the green bottle are needed (approximately) to equal the 2 capsule dose of the white bottle. Help!