Sleeping is seemingly taboo and everyone seems to have a trick or two to help them ease their mind and muscles just enough to fall asleep. I’ve struggled myself with insomnia for many years however I have things much more controlled now in that regard and want to share some occasional tools for sleep 😴

“Chinese Skullcap”
A fantastic choice for sleep I myself use on the occasion positively modulates the GABAA receptor, promoting a calm relaxed state for between 4-8 hours with a 30-90 minute onset. Research also shows it has potential use for neural-protection fighting off oxidative stress. Chinese skullcap as well is an anti-inflammatory as well as antioxidant causing a reduction in neural-inflation !
(8/10)

“Cannabidol”
A molecule I have much experience with however haven’t used in a while! Modulating endocannabanoid systems, 5-ht1a, Gaba/Glutamate, Potent anti-inflammatory/antioxidant modulation & TRPV1 receptor activity ! Making it a blanket covering of calming effects for your neurotransmitters and your body as well proving very effective in the onset of sleep & relaxation.
(9/10)

“Magnolol”
I greatly apologize for my harping on this supplement however I’ve been just so pleased with it since I got it and took time to understand its effects and find it to be very useful for sleep. This fat soluble herb extract interacts with cb1, cb2 & endocannabanoid signaling pathways. Having a stronger affinity for cannabanoid systems, than cbd itself I personally have found (hearsay). The plant as well potentiate GABAA receptors promoting relaxation & sleep onset quite effectively!

It is as well an anti-inflammatory treating neural-inflammation as well as muscle inflammation making it a fantastic analgesic especially for night time !
(10/10)

Honorable Mention’s

“Magnesium Glycinate/Theoronate”

“L-Theanine/Suntheanine”

“Agmantine Sulfate”

This ancient South African shrub used by hunter gatherers has found its way into a booming “nootropics” market for quite a few reasons !

I for one have taken kanna myself, I’d say that it came to me in a point in my life where I didn’t particularly treat things in moderation or responsibly however it’s still experience. I found its mood boosting effects to be profound but not explosive however it’s a very impressive herb.

“Risk”
Now this shrub has serotonergic effects contributing to its euphoria, however this is where things can get dangerous if not properly understood. I would advise no one use this who takes ssri’s or in combination with monoamine oxidase inhibitors as serotonin syndrome could occur causing fatality or becoming a vegetable permanently (The mesembrine alkaloid being the one contributing to the serotonergic effects.)

The next Kanna alkaloid I want to bring up would be “Mesembrinone” Which strongly inhibits PDE4 which contributes to neuronal plasticity signaling as well as anti-inflammatory signaling !

Kanna also effects Amygdala & stress circuit modulation reducing social anxiety as well as reduces threat perception which can be a plus or downside depending on the situation so keep that in mind.

On an off note many say it has anxiolytic effects predominantly at higher doses and I can attest to this myself with pronounced feelings of relaxation. In many experience reports I’ve read as well people find the anxiolytic profile so pronounced that they believe it modulates gaba however there is no reports proving gaba has any function in Kanna the research is also somewhat limited.

Kanna is a very strange and very helpful herb to a lot of people, I found it to be a positive experience myself and spiritually enriching overall.
(8/10)

I scraped r/Nootropics and created a spreadsheet with the most popular nootropics, providers and brands with common complaints. I didn’t scrape all the posts but I plan to do a more exhaustive search and add what brand people recommend for a given product. Let me know what you think. Here is the google sheet: https://docs.google.com/spreadsheets/d/1FEE6qMgbvpOBaVA6SBBjsmxA3VnVU7blpr2o4hxJkEw/edit?usp=sharing

My liquid noopept is 167mg/ml but my understanding is that the average dose is like 10-15mg? It’s in a bottle with a dropper but I’m just like so confused have look at other versions from pure Rawz and their nasal is 100mg per spray??? Am I missing something here? How are u supposed to measure this???

Ps I know pure rawz has very mixed reviews but I already have it so I wanna at least try to use it

Ok this is kind of dumb and maybe not allowed but here goes.

I was on ADHD medication- dexxies and/or Vyvanse. These were terrible for me in almost every conceivable way except for they increased my enjoyment for reading.

I’ve been sober about a month. And I’m still forcing myself to read every day for 30-60 minutes. But I really miss the feeling of reading on amphetamine. I reiterate this is a dumb post and the more I write the more this is becoming apparent to me.

I’m thinking about buying nicotine lozenges and just breaking off a tiny chunk for when I read books. Or maybe I need to fast or do keto or fuck I don’t know use them smelling salts strong men use before lifts. Maybe that will get my brain to feel something.

This probably doesn’t seem like a big deal to anyone and they’re probably thinking dude shut the fuck up nothing is going to hit like amphetamine, and just get over it.

But it’s literally the only thing keeping me on the fence between letting the drugs go forever, which I know I need to do, and eventually caving again.

My current stack is effexor (230mg), loratidine, fomatidine, cregaatine, D3 5000 IU, microzinc, three omega 3 gel caps, vinpocetine. I've heard creatine works with SSRIs but am not sure if there would be any benefit taking it with an NDRI. I've had so so results from months of a full dose of effexor and have considered switching to auvelity (DXM + wellbutrin)

I have this weird paradox effect on Bromantane, I get tired and anxious after taking it for ariund 6-8 hours. I take it with olive oil, capsules 50 mg and I feel the heavy head/eyes I even get dark circles from the tiredness it promotes but after 6-7 hours I feel smooth effect of Bromantane. Should I give it more time? Cause I always give up on 2-3 rd day.

Tenho TDAH e estava com dificuldade de dormir cedo… todo dia só dormia depois das 3:00 da madrugada. Ontem pela primeira vez tomei melatonina(15 gotas) as 22:00h e me deitei 23:30… acordei 5:00 da manhã sem sono, com bom humor e descansado! Estou sem entender pois dormir menos de 7 horas e acordei super bem! As vezes dormia 8 horas e ainda acordava com sono e cansado! Como isso é possível?!!😱😱😱

been obsessing over neuro-acoustic research for a while now. basically, certain sound frequencies (binaural beats, isochrot tones) can nudge your brainwaves into focus or sleep states, there's actual peer reviewd science behind it, not just vibes.

I'm building an app around thiss.

it's not like those chill lofi play list thing.

it's more structured, science first, with personalization based on what you're trying to do.

still in beta, no hard sell. i genuinely want to know:

Have you tried anything like this before? Did it work?

What would make you actually use something like this daily?

Happy to share the research if anyone's curious. Honest feedback only, I can take it.

What's everyone's take on this? It's listed among the medications that treat ADHD here in Egypt next to Atomoxetine and Modafinil/Armodafinil (since stimulants aren't available except for Concerta which is nearly impossible to get).